An accessory peptide binding site with allosteric effect on the formation of peptide-MHC-II complexes?
Identifieur interne : 000293 ( France/Analysis ); précédent : 000292; suivant : 000294An accessory peptide binding site with allosteric effect on the formation of peptide-MHC-II complexes?
Auteurs : Denis Gerlier [France] ; Marie-Claude Trescol-Biémont [France] ; Laurent Ettouati [France] ; Joëlle Paris [France] ; Chantai Rabourdin-Combe [France]Source :
- Comptes Rendus de l'Academie des Sciences Series III Sciences de la Vie [ 0764-4469 ] ; 1998.
English descriptors
- KwdEn :
- Teeft :
- Accessory, Accessory binding site, Accessory peptide binding site, Allosteric, Allosteric effect, Antigen processing, Bind molecules, Binding groove, Binding peptide, Binding site, Cell surface, Cognate, Cognate peptide, Complex formation, Groove, Invariant chain, Life sciences, Molecule, Niche, Peptide, Second peptide, Short peptides, Structural requirements, Yrmklpksakpvsqmr yrmklpkppkpvsqmr.
Abstract
Abstract: MHC-II molecules bind a single peptide in their groove. Here, the authors summarise evidence that a second peptide could bind transiently to MHC-II molecules outside the groove and have an allosteric effect on peptide-MHC-II complex formation. This effect could modulate, after the antigen processing, the selection of the peptide subset presented by MHC-II molecules to the helper CD4 T cells, which regulate the specific immune response.
Résumé Les molécules du complexe majeur d'histocompatibilité de classe II (CMH-II) lient un seul peptidc dans leur niche. Certaines données expérimentales indiquent qu'il existe, en dehors de cette niche, un site accessoire de liaison pour un second peptide capable d'exercer un effet allostérique sur la formation des complexes peptide-CMH-II. Cet effet pourrait, après l'apprêtcment de l'antigène, moduler la sélection du sous-ensemble de peptides présentés par les molécules CMH-II aux lymphocytes T CD4 auxiliaites, qui sont les régulateurs de la réponse immunitaire.
Url:
DOI: 10.1016/S0764-4469(97)89621-7
Affiliations:
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ISTEX:9FE7BB658C0FA04FE4F30B3C8DEB60B95133B613Le document en format XML
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nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region><settlement type="city">Lyon cedcx 07</settlement></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Comptes Rendus de l'Academie des Sciences Series III Sciences de la Vie</title><title level="j" type="abbrev">PXVOLD</title><idno type="ISSN">0764-4469</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1998">1998</date><biblScope unit="volume">321</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="19">19</biblScope><biblScope unit="page" to="24">24</biblScope></imprint><idno type="ISSN">0764-4469</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0764-4469</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>HEL</term><term>MHC-II</term><term>SDS-PACE</term><term>SEB</term><term>Sigles APC</term><term>allostery</term><term>invariant chain</term><term>major histocompatibility complex class II</term><term>mli</term><term>peptide binding</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Accessory</term><term>Accessory binding site</term><term>Accessory peptide binding site</term><term>Allosteric</term><term>Allosteric effect</term><term>Antigen processing</term><term>Bind molecules</term><term>Binding groove</term><term>Binding peptide</term><term>Binding site</term><term>Cell surface</term><term>Cognate</term><term>Cognate peptide</term><term>Complex formation</term><term>Groove</term><term>Invariant chain</term><term>Life sciences</term><term>Molecule</term><term>Niche</term><term>Peptide</term><term>Second peptide</term><term>Short peptides</term><term>Structural requirements</term><term>Yrmklpksakpvsqmr yrmklpkppkpvsqmr</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: MHC-II molecules bind a single peptide in their groove. Here, the authors summarise evidence that a second peptide could bind transiently to MHC-II molecules outside the groove and have an allosteric effect on peptide-MHC-II complex formation. This effect could modulate, after the antigen processing, the selection of the peptide subset presented by MHC-II molecules to the helper CD4 T cells, which regulate the specific immune response.</div><div type="abstract" xml:lang="fr">Résumé Les molécules du complexe majeur d'histocompatibilité de classe II (CMH-II) lient un seul peptidc dans leur niche. Certaines données expérimentales indiquent qu'il existe, en dehors de cette niche, un site accessoire de liaison pour un second peptide capable d'exercer un effet allostérique sur la formation des complexes peptide-CMH-II. Cet effet pourrait, après l'apprêtcment de l'antigène, moduler la sélection du sous-ensemble de peptides présentés par les molécules CMH-II aux lymphocytes T CD4 auxiliaites, qui sont les régulateurs de la réponse immunitaire.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Auvergne-Rhône-Alpes</li><li>Rhône-Alpes</li></region><settlement><li>Lyon</li><li>Lyon cedcx 07</li></settlement></list><tree><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Gerlier, Denis" sort="Gerlier, Denis" uniqKey="Gerlier D" first="Denis" last="Gerlier">Denis Gerlier</name></region><name sortKey="Ettouati, Laurent" sort="Ettouati, Laurent" uniqKey="Ettouati L" first="Laurent" last="Ettouati">Laurent Ettouati</name><name sortKey="Paris, Joelle" sort="Paris, Joelle" uniqKey="Paris J" first="Joëlle" last="Paris">Joëlle Paris</name><name sortKey="Rabourdin Combe, Chantai" sort="Rabourdin Combe, Chantai" uniqKey="Rabourdin Combe C" first="Chantai" last="Rabourdin-Combe">Chantai Rabourdin-Combe</name><name sortKey="Trescol Biemont, Marie Claude" sort="Trescol Biemont, Marie Claude" uniqKey="Trescol Biemont M" first="Marie-Claude" last="Trescol-Biémont">Marie-Claude Trescol-Biémont</name><name sortKey="Trescol Biemont, Marie Claude" sort="Trescol Biemont, Marie Claude" uniqKey="Trescol Biemont M" first="Marie-Claude" last="Trescol-Biémont">Marie-Claude Trescol-Biémont</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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